Objective: To determine if a baseline hsTnT value ≤99th percentile upper reference limit (0.014 ug/L (“low hsTnT”)) identifies patients at low risk for adverse events. Methods: RELAX-AHF randomized AHF patients who were dyspneic, congested, with a SBP ≥125mmHg, moderate renal impairment, NT-proBNP ≥1600ng/L, and enrolled within 16 hours of presentation to serelaxin vs. placebo.

We performed a nested prospective biomarker study in 6308 patients, analysing hsTnT, NT-proBNP, and GDF-15 at baseline and 12 months. hsTnT was dynamic in 46.9% (≥2 ng/L change), NT-proBNP in 51.9% (≥200 pg/mL change), GDF-15 in 45.6% (≥300 pg/mL change) during 12 months.

2014-10-02 · At baseline, hsTnT levels ranged from ≤5.0 to 378.7 pg/ml, and NT-proBNP levels ranged from ≤5 to 35,000 pg/ml. Compared with those who had undetectable hsTnT, participants in the highest quartile (>26.5 ng/ml) had a significantly higher rate of HF (hazard ratio, 4.77; 95% confidence interval, 2.49 to 9.14). 2017-04-05 · The median baseline hsTnT level was 0.033 ng/ml, which was comparable with our study. They concluded that baseline, peak, and peak change in hsTnT (largest change from baseline and peak hsTnT level) were associated with 180-day cardiovascular mortality. Our results are somewhat different from those of the above study.

Observe (ACS Probability: 25%). Suggested Management: • Requires further troponin testing in 4h. 9 Jun 2018 Conclusions: A single baseline hs-cTnT level less than the LoD of 6 ng/L can be used to rule-out AMI, and identifies a low risk population which 16 Nov 2019 To evaluate the association of baseline hsTnT and NT-proBNP levels with CV death/HHF in patients with and without prior HF and with. Increased baseline hsTnT levels occurred in 78% of all patients. Peri-procedural myocardial infarction was not registered in any of the two groups (Table 2).

In multivariable linear regression analysis, there were significant correla- tions between hsTnT at baseline and age, male gender, creatinine, left ventricular mass

12 Mar 2018 Baseline values of high sensitive troponin T (hsTnT), interleukin (IL)-6, and C- reactive protein. (CRP) did not differ significantly in both groups, 21 Dec 2017 The hsTnT assay implemented in 16 Swedish hospitals was the current have also shown that in patients with baseline hsTnT elevation with a 25 Mar 2012 NT-proBNP and hsTnT levels were measured at baseline and after 2-3 years in older adults without HF in the Cardiovascular Health Study 9 Aug 2008 Median baseline hsTnT concentrations (25th, 75th percentile) were comparable in patients with reversible, fixed, and no PDs [5.57 (2.47, 13 Apr 2016 The hsTnT assay reliably measures small elevations of this cardiac hsTnT or cTnI, the choice of lab for establishing baselines should be 19 Jun 2014 Thursday is TechTip Day!Applications Analyst Jaques Loubens takes us through Q2000 PCA Data Analysis in this week's new TA TechTip! 10 Sep 2012 If you do it the manual way, you set the baseline range under Analysis Settings.

Combination of baseline hsTnT levels with the sPESI allowed a more reliable identification of patients with a favorable long-term (6-month) prognosis (Figure 3, bottom, P<0.001; and Figure 4). Only 1 patient (0.8 [0.0–4.3]%) with a sPESI of 0 and hsTnT <14 pg/mL died within the 6-month follow-up period.

The median for hsTnT at first postoperative day was 235 ng/L (152-425 ng/L).

hsTnT were available in 888 patients (438 without diabetic nephropathy, 450 with diabetic nephropathy). Of these, 104 patients had hsTnT levels below the detection limit. At baseline, hsTnT was higher in patients with diabetic ne-phropathy than in patients with normoalbuminuria (median [interquartile range]: 8.9 [4.1–17.2] vs. 3.1 [1.1–6.0 Combination of baseline hsTnT levels with the sPESI allowed a more reliable identification of patients with a favorable long-term (6-month) prognosis (Figure 3, bottom, P<0.001; and Figure 4). Only 1 patient (0.8 [0.0–4.3]%) with a sPESI of 0 and hsTnT <14 pg/mL died within the 6-month follow-up period. This is seemingly contradicted by Reichlin et al., who claimed that a simple algorithm incorporating hsTnT baseline values and absolute changes within the first hour allowed a safe rule-out and an accurate rule-in of AMI in 77% of randomly selected patients with acute chest pain [65].
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26,27 However, in our study, a single hsTnT level of 19 ng/L or less is probably inadequate because it provided an AMI NPV of only 98.2% at baseline presentation. 2019-07-10 · No patient with a low hsTnT – regardless of baseline or 3-hour draw or cut-point – died within 30 days. Only one patient with a hsTnT < 14ng/L at baseline died within 90 days. Among patients with serial troponins, no patient with hsTnT < 14 ng/L at 0 and 3 hours died by 90 days. elevation.

Baseline NT‐proBNP and hsTnT levels were measured in the TIMI Clinical Trials Laboratory in 14 565 patients. Among the included patients, 9143 patients (62.8%) were male, 1464 (10.1%) had a history of HF and the mean age was 63.9.
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We hypothesized that baseline N‐terminal pro B‐type natriuretic peptide (NT‐proBNP) and high‐sensitivity troponin T (hsTnT) levels would help identify patients who are at higher baseline risk and we describe the treatment effects of dapagliflozin in patients according to their baseline NT‐proBNP and hsTnT levels. Methods and results

22 Jan 2015 ABSTRACT High-sensitivity troponin T (hsTnT) helps in identifying pulmonary TABLE 1 Baseline characteristics, medical history, and initial Baseline hsTnT 13-51ng/L. OR. Delta hsTnT 3-4ng/L at 1 hr.

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Whereas hsTnT levels were <14 ng/L (limit of quantification) in these control subjects (3.34 ng/L, 3.96 ng/L and 5.97 ng/L), hsTnT baseline values were >14 ng/L and thus pathologically elevated in 4 patients. Elevated hsTnT levels are associated with death and decreased right ventricle function in patients with PAH .

Among the included patients, 9143 patients (62.8%) were male, 1464 (10.1%) had a history of HF and the mean age was 63.9. Severe hypoglycemia was associated with 34% higher 1-year hsTnT levels (p < 0.0001) in unadjusted analysis, 17% higher (p = 0.006) after adjustment for baseline factors unrelated to diabetes, and 6% higher (p = 0.23) after further adjustment for the duration and severity of diabetes. Ankle brachial pressure index (ABI), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hsTnT) were measured at baseline. Pulse wave velocity (PWV) and carotid intima media thickness were measured 1 year into follow-up. Data were analysed using Cox proportional hazards models. The newest high sensitive 5th generation cardiac TnT assay (hsTnT) detects an elevation in TnT levels within 1 hour of the onset of myocardial infarction.1 It also measures low levels of TnT that were undetectable in prior assay generations, in subjects that do not have myocardial infarction.

A single hsTnT level less than 6 ng/L was associated with a markedly decreased risk of AMI, while serial levels at 19 ng/L or less identified patients at less than 1% risk of 30-day ACE. Efficacy of High-Sensitivity Troponin T in Identifying Very-Low-Risk Patients With Possible Acute Coronary Syndrome

None of the factors was helpful to differentiate MI and NSM. High-sensitivity troponin T (hsTnT) is a marker of cardiovascular disease (CVD) and in type 2 diabetes also a marker of renal events, but has not been evaluated in type 1 diabetics. We therefore reviewed a type 1 diabetes cohort of 442 without and 458 with diabetic nephropathy.

Severe hypoglycemia was associated with 34% higher 1-year hsTnT levels (p < 0.0001) in unadjusted analysis, 17% higher (p = 0.006) after adjustment for baseline factors unrelated to diabetes, and 6% higher (p = 0.23) after further adjustment for the duration and severity of diabetes.